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Be sure your doctor and lab personnel know you are taking Colchicine/Probenecid. Caution and careful attention to dosage are recommended to prevent accumulation and toxicity if colchicine is administered to these patients {05} {10}. In addition, colchicine has been found to reverse abnormalities in neutrophil activity that are present in patients with Beh?et's disease, i. Colchicine inhibits secretion of serum amyloid A in patients with familial Mediterranean fever {04}. {01} {02} {03} {04} {05} {06} {07} Prophylactic administration of colchicine may be especially important during the first several months of treatment with an antihyperuricemic agent (allopurinol, probenecid, or sulfinpyrazone) because the frequency of acute attacks may be increased when such therapy is initiated. Prophylactic use of colchicine is therefore recommended for all patients with familial Mediterranean fever, even when frequent, severe attacks continue to occur despite colchicine administration {11}.

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