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Mefloquine may be considered for use when travel to areas with chloroquine-resistant P. In addition, severe reactions and sudden death have been reported following parenteral administration of chloroquine in children. When chloroquine is used for the short-term treatment of malaria or other parasitic diseases, side/adverse effects are usually mild and reversible {01} {02} {06}. The combination of chloroquine and proguanil for sub-Saharan Africa has lower efficacy than other regimens {41}. To avoid relapse, after initial treatment of the acute infection with chloroquine, patients should subsequently be treated with an 8-aminoquinolone (e.

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